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KMID : 1140120090140040303
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Cancer Prevention Research
2009 Volume.14 No. 4 p.303 ~ p.308
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A Study on the Association between Ambient Particles and Urinary Malondialdehyde in Children
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Song Sang-Hwan
Lee Chul-Woo
Park Choong-Hee
Heo Won-Jun
Lee Young-Mee
Kim Dae-Seon
Han Jin-Seok
Seo Young-Rok
Yu Seung-Do
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Abstract
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Oxidative stress is believed to be involved in particulate related cancer process. We investigated urinary malondialdehyde (MDA) levels, biomarker of lipid peroxidation, of 53 schoolchildren from two urban areas. The associations between MDA levels and ambient particulate matters of different size (PM10, PM2.5, PM1, PM10-2.5 and PM2.5-1) were estimated. The urinary MDA was analysed by thiobabituric acid reaction and HPLC. Mean level of MDA in children was 1.16 (Seoul panel) and 1.26 (Incheon panel)?mol/g creatinine. Linear mixed regression analyses showed that the coarse fractions of PM (PM10-2.5, PM2.5-1) were consistently associated with increase in urinary MDA. This results indicate that ambient particles induce oxidative stress biomarker which involved in mechanism of cancer process.
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KEYWORD
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Particulate matter, Malondialdehyde, Children, Lipid peroxidation
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